Review Paper
Evaluating Biomaterial-and Microfluidic-Based 3D Tumor Models
Abstract
Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase in the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. We review the current "state-of-the-art" in 3D Tissue Engineering (TE) models developed for and used in cancer research. Scaffold-based TE models and microfluidics, are assessed for their potential to fill the gap between 2D models and clinical application. Recent advances in combining the principles of 3D TE models and microfluidics are discussed, with a special focus on biomaterials and the most promising chip-based 3D models.
Journal
Trends in Biotechnology
Volume
33
Issue
11
Pagination
667–678
Publisher
Elsevier
ISSN
0167-7799
URL
http://www.sciencedirect.com/science/article/pii/S016777991500195XKeywords
Biomaterials, cancer microenvironment, drug discovery, MicrofluidicsRights
Open Access
Peer Reviewed
Yes
Status
published
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