Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

last updated: 2020-08-06
ProjectPATH - Programa de Doutoramento Norte 2020 :: publications list
TitleVescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
Publication TypePapers in Scientific Journals
Year of Publication2020
AuthorsAraújo A. R., Gigante S. C., Taboada P., Reis R. L., and Pires R. A.
Abstract

The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.

 

JournalChemical Communications
Volume56
Issue21
Pagination3187-3190
Date Published2020-02-10
PublisherThe Royal Society of Chemistry
ISSN1359-7345
DOI10.1039/D0CC00192A
URLhttps://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc00192a/unauth#!divAbstract
KeywordsAlzheimer's disease, amyloid-beta, natural polyphenols
RightsopenAccess
Peer reviewedyes
Statuspublished

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