Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents To Recover Astaxanthin from Brown Crab Shell Residues

Abstract

The potential of natural deep eutectic systems
(NADESs) to efficiently extract astaxanthin (AXT) contained in
crab shell wastes was evaluated. Different terpene-based mixtures
were prepared and characterized. Aiming at maximizing the AXT
recovery, we evaluated the effect of operating temperature and time
on the extraction performance. As a proof of concept, this paper
also highlights the potential of NADESs for AXT extraction from
shrimp shells, mussels, and Haematococcus pluvialis. The biological
potential of AXT-rich extracts; the AXT standard; and NADESs,
their individual components, and equivalent physical mixtures was
evaluated, including cytotoxicity, antiproliferative effects on human colorectal cancer cells, and antimicrobial potential against Staphylococcus aureus and Escherichia coli. Results showed that extractions with menthol:myristic acid (8:1) were able to match the AXT yield obtained by a Soxhlet extraction with acetone. Additionally, when using the same NADESs to recover AXT from the other biomasses under study, there was a 3- to 657-fold increase in yields when compared with the Soxhlet extraction. AXT-rich extracts obtained with NADESs showed antiproliferative and antimicrobial potential. This study suggests that NADESs can truly be used as alternative extraction media for the recovery of AXT from waste biomass and that these systems and respective extracts have the potential to be used as ingredients in industrial applications.

Journal
ACS Sustainable Chemistry Engineering
Volume
8
Issue
5
Pagination
2246–2259
Publisher
ACS
ISSN
2168-0485
ISBN
2168-0485
URL
https://pubs.acs.org/doi/full/10.1021/acssuschemeng.9b06283
Keywords
antiproliferative and antimicrobial effects, astaxanthin, bioactive extracts, biorefinery, Natural deep eutectic solvents, shell residues
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
Dez.Zyme
Year of Publication
2020
DOI
10.1021/acssuschemeng.9b06283
Date Published
2020-01-27
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