Synthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications

last updated: 2021-01-21
Project IF/01285/2015 :: publications list
TitleSynthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications
Publication TypePapers in Scientific Journals
Year of Publication2021
AuthorsTeixeira J. V. U., Maia F. R., Carvalho M. R., Reis R. L., Dr. Oliveira J. M., Lisboa-Filho P. N., and Claro A. P. R. A.

Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations.

Date Published2021-01-07
PublisherFuture Medicine
Keywordscore/shell, cytotoxicity, gallium incorporation, nanoparticle synthesis
Peer reviewedyes

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