The Potential of Hyaluronic acid in Immunoprotection and Immunomodulation: Chemistry, Processing and Function

last updated: 2018-04-27
TitleThe Potential of Hyaluronic acid in Immunoprotection and Immunomodulation: Chemistry, Processing and Function
Publication TypeReview Paper
Year of Publication2018
AuthorsZamboni F., Vieira S., Reis R. L., Dr. Oliveira J. M., and Collins M. N.
Abstract Text

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterials science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. This paper reviews the recent researchon the role of HAas a immunoprotective and immunomodulatory biomaterial and the importance of HA in combating immune related diseases such as type 1 diabetes, cancer, and autoimmunity. The chemical modifications and processing methods employed to produce HA-modified materials are discussed, thus giving a better understanding of the structure-function-property relationships that influence immunomodulation, immunoprotection and stability. The article concludeswith a discussion on the latest progress in HA materials science which is enabling the realisation of new therapies such as vaccine delivery, immunotherapy, cell encapsulation and transplantation.

JournalProgress in Materials Science
Volume97
Pagination97-122
Date Published2018-04-22
PublisherElsevier
ISSN0079-6425
DOI10.1016/j.pmatsci.2018.04.003
URLhttps://ac.els-cdn.com/S0079642518300495/1-s2.0-S0079642518300495-main.pdf?_tid=54a57ecd-42d5-462a-ab6e-8ce02c3f4791&acdnat=1524750911_a62e328de47b4952503c0193c1190390
Keywordscell encapsulation, ecm, HA, Immunomodulation, Immunoprotection, vascularization
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

Back to top