Biomaterials, Biodegradables and Biomimetics Research Group

Review Paper

The Potential of Hyaluronic acid in Immunoprotection and Immunomodulation: Chemistry, Processing and Function

Abstract

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterials science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. This paper reviews the recent researchon the role of HAas a immunoprotective and immunomodulatory biomaterial and the importance of HA in combating immune related diseases such as type 1 diabetes, cancer, and autoimmunity. The chemical modifications and processing methods employed to produce HA-modified materials are discussed, thus giving a better understanding of the structure-function-property relationships that influence immunomodulation, immunoprotection and stability. The article concludeswith a discussion on the latest progress in HA materials science which is enabling the realisation of new therapies such as vaccine delivery, immunotherapy, cell encapsulation and transplantation.

Journal
Progress in Materials Science
Volume
97
Pagination
97-122
Publisher
Elsevier
ISSN
0079-6425
URL
https://ac.els-cdn.com/S0079642518300495/1-s2.0-S0079642518300495-main.pdf?_tid=54a57ecd-42d5-462a-ab6e-8ce02c3f4791&acdnat=1524750911_a62e328de47b4952503c0193c1190390
Keywords
cell encapsulation, ecm, HA, Immunomodulation, Immunoprotection, vascularization
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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