Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

PAMAM Dendrimers Functionalised with an Anti-TNF α Antibody and Chondroitin Sulphate for Treatment of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein we aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF α antibodies (Abs) to provide anti-inflammatory properties. Physicochemical characterisation demonstrated that anti-TNFα Abs-CS/PAMAM dendrimer NPs were successfully produced. The in vitro studies revealed that CS/PAMAM dendrimer NPs did not affect the ATDC5 and THP-1 cell lines’ metabolic activity and proliferation, presenting good cytocompatibility and hemocompatibility. Moreover, anti-TNFα Abs-CS/PAMAM dendrimer NPs showed suitable TNF α capture capacity, making them appealing for new immunotherapies in RA patients.

Journal
Materials Science and Engineering: C
Pagination
111845
Publisher
Elsevier
ISSN
0928-4931
URL
https://www.sciencedirect.com/science/article/pii/S0928493120337644?via%3Dihub
Keywords
Anti-TNF α, Chondroitin sulphate, inflamed joint, PAMAM dendrimer, Polyclonal antibody, rheumatoid arthritis
Rights
Open Access
Peer Reviewed
Yes
Status
published
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