Biomaterials, Biodegradables and Biomimetics Research Group

Book Chapter

Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide

Abstract

Diabetes mellitus type 2 (type-2 diabetes) is a metabolic disorder characterized by the increased blood glucose concentration and insulin resistance in peripheral tissues (e.g., muscles and adipose tissue). The initiation of the pathological cascade of events that lead to type-2 diabetes has been subject of debate; however, it has been commonly accepted that the oversecretion of human islet amyloid polypeptide (hIAPP, a hormone co-secreted with insulin) by the pancreatic

Journal
Biomimicked Biomaterials
Volume
1250
Pagination
159-176
Publisher
Springer, Singapore
ISBN
978-981-15-3261-0
URL
https://pubmed.ncbi.nlm.nih.gov/32601944/
Keywords
Amylin, Amyloid, Diabetes mellitus type 2, Islet amyloid polypeptide, natural polyphenols, protein aggregation
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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