Biomaterials, Biodegradables and Biomimetics Research Group

Comunications - Poster

Microparticles and Hydrogels for Ischemic Stroke Imaging and Recovery

Abstract

Stroke patients suffer impairments for life, as current treatments are mostly palliative and offer unsatisfactory results regarding brain regeneration1,2. The present work aims to develop an approach for Mesenchymal Stem Cells (MSCs) transplantation that makes use of injectable hydrogels, namely Mn2+-crosslinked Thiolated Hyaluronic Acid and methacrylated Gellan Gum. The cell-laden hydrogels will aid neural repair, while Mn2+ incorporation will allow their MRI imaging and investigate their fate in vivo. Growth-factor loaded Nanoparticles will be added to the hydrogels to support host/transplanted cells. These scaffolds will be tested in an animal model of stroke, obtained by microparticles (MPs) containing Mn2+/iron-oxide, which will be injected to produce an artificial brain clog for 30 minutes, originating a stroke-like injury. The MPs were injected through catheters of two sizes without clogging and maintained their shape. The MRI analysis showed that Mn2+/Iron-oxide are good candidates for MRI contrasts, as from 0.5 to 2 mg/mL they produced a signal in T1/T2. Future work will consist on optimizing its release rate, the analysis of hydrogel’s mechanical properties and their biocompatibility with MSCs.

Journal
1st Discoveries Forum on Regenerative and Precision Medicine
Keywords
Biomaterials, MRI, Stem cells, Stroke, Tissue engineering
Rights
Open Access
Peer Reviewed
Yes
Status
published
Project
NanoTech4ALS
Year of Publication
2019
DOI
0000000
Date Published
2019-09-25
Search Google ScholarGenerate BibTexDownload RTF
This website uses cookies. By using this website you consent to our use of these cookies. For more information visit our Policy Page.