Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Methacrylated gellan gum and hyaluronic acid hydrogel blends for image-guided neurointerventions

Abstract

Cell-based therapies deliveredviaintrathecal injection are considered as one of the most promisingsolutions for the treatment of amyotrophic lateral sclerosis (ALS). Herein, injectable manganese-basedbiocompatible hydrogel blends were developed, that can allow image-guided cell delivery. Thehydrogels can also provide physical support for cells during injection, and at the intrathecal space aftertransplantation, while assuring cell survival. In this regard, different formulations of methacrylated gellangum/hyaluronic acid hydrogel blends (GG-MA/HA) were considered as a vehicle for cell delivery. Thehydrogels blends were supplemented with paramagnetic Mn2+to allow a real-time monitorization ofhydrogel depositionvia T1-weighted magnetic resonance imaging (MRI). The developed hydrogels wereeasily extruded and formed a stable fiber upon injection into the cerebrospinal fluid. Hydrogels preparedwith a 75 : 25 GG-MA to HA ratio supplemented with MnCl2at 0.1 mM showed controlled hydrogeldegradation, suitable permeability, and a distinct MRI signalin vitroandin vivo. Additionally, human-derived adipose stem cells encapsulated in 75 : 25 GG-MA/HA hydrogels remained viable for up to14 days of culturein vitro. Therefore, the engineered hydrogels can be an excellent tool for injectableimage-guided cell delivery approaches.

Journal
Journal Materials Chemistry B
Volume
8
Pagination
5928-5937
Publisher
The Royal Society of Chemistry
ISSN
2050-7518
URL
https://pubs.rsc.org/en/journals/journalissues/tb?_ga=2.123370123.1699957818.1592401305-1323950356.1592401304#!recentarticles&adv
Keywords
hydrogel, MRI imaging, neurointervention
Rights
Closed Access
Peer Reviewed
Yes
Status
published
Project
NanoTech4ALS
Year of Publication
2020
DOI
10.1039/d0tb00877j
Date Published
2020-06-16
Search Google ScholarGenerate BibTexDownload RTF
This website uses cookies. By using this website you consent to our use of these cookies. For more information visit our Policy Page.