For many years Peripheral Nerve Injuries (PNI) have been major concerns in regenerative medicine. Currently, the gold standard treatment for PNI is autologous nerve grafting. Many engineered biomaterials, natural or synthetic, have been studied in order to achieve a successful nerve guidance tube and overcome autografts limitations [1]. In this study, an innovative combination of chitosan and keratin is obtained in order to create a novel nerve conduit (medical device) aimed at finding applications in the treatment of PNI.