Biomaterials, Biodegradables and Biomimetics Research Group

Comunication - Oral

Investigation of Dendrimer-based nanoparticles cellular uptake and cell tracking in a semi-automated microfluidic platform

Abstract

Circulating tumor cells (CTCs) have been highly studied due to its implication in cancer dissemination and metastases. Thus, an approach capable of hindering their dissemination could help prevent 90% of cancer deaths (1). Labeled nanoparticles (NPs) have been proposed to track cells and monitor the efficiency of any new cancer therapy in real time. The association of NPs to a microfluidic device, such as Vena8 biochips (Figure 2), allows the accomplishment of functions in vitro that are not easily imaginable in conventional biological analysis (e.g., simulation of physiological flow and shear stress). This novel approach may expedite therapies’ validation and its successful translation into clinics. In this study, we aim to develop an improved platform composed of labeled dendrimer nanoparticles and a microfluidic device for real-time monitoring of cancer cells fate.

Journal
Society for Biomaterials 2015
Keywords
Cancer cells, Microfluidics, Nanoparticles
Rights
Closed Access
Peer Reviewed
Yes
Status
published
Project
HierarchiTech
Year of Publication
2015
DOI
000000000
Date Published
2015-04-17
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