Bioceramics, natural and synthetic, have been developed to repair, reconstruct, and substitute diseased parts of the body and to promote tissue healing as an alternative to metallic implants. Applications embrace hip, knee, and ligament repair and replacement, maxillofacial reconstruction and augmentation, spinal fusion, bone filler, and repair of periodontal diseases.¹

Hierarchically structured nanocomposites comprising levels from the macroscopic tissue arrangement down to the molecular arrangement of proteins, have a great potential in tissue engineering and regenerative medicine. The nanoscale of the materials can provide a dramatic improvement in the mechanical performance and in the transduction of the mechanical stimuli to the cellular level.² Innovative bioceramics-biopolymer nanocomposites are able to bolster scientific efforts for tissue regeneration because of the excellent combination of bioactivity and osteoconductivity of the bioceramics, and the flexibility and shape controllability of the biopolymers. Furthermore, the incorporation of different ions (e.g. strontium, zinc, magnesium, manganese, silicon) into the nanocomposites showed an ionic released during bone graft resorption, and hence an influence in bone health, while strengthening the mechanical properties of the implants.³ Besides, minerals and traces of metal elements may provide physicochemical modifications in the produced materials, which can accelerate bone formation and resorption in vivo.³ In this study, we aim to evaluate calcium phosphates-based nanocomposites doped with different ions, namely related to their structural and mechanical properties, as well as cell proliferation and osteogenesis, towards tissue regeneration.