Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models

Abstract

Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model
gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.

Journal
Cancer Letters
Volume
504
Pagination
116-124
Publisher
Elsevier
ISSN
0304-3835
URL
https://www.sciencedirect.com/science/article/pii/S0304383521000471?via%3Dihub
Keywords
bioengineering, Externally driven assembly, Organ on a chip, personalized medicine, self-assembly
Rights
Restricted Access (2 Years)
Peer Reviewed
Yes
Status
published
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