Chitosan films with varying degrees of acetylation for application in peripheral nerve regeneration

last updated: 2020-01-13
ProjectBioHybrid :: publications list
TitleChitosan films with varying degrees of acetylation for application in peripheral nerve regeneration
Publication TypeComunications - Poster
Year of Publication2016
AuthorsCarvalho C. R., López-Cebral R., Silva-Correia J., Silva J. M., Mano J. F., Silva T. H., Freier T., Reis R. L., and Dr. Oliveira J. M.
Abstract

Damage to the Peripheral Nervous System (PNS) is remarkably common and occurs mainly as a result from trauma or complications of surgery [1]. Although recovery of nerve function occurs in some mild
injuries, outcomes are frequently poor following severe trauma, resulting in long-term impairment of
limb function, dysaesthesia and pain, often with associated psychological effects [2]. As consequence,
this issue has been raising major concerns in regenerative medicine for several years as unsatisfactory recovery continues to be a significant clinical challenge [3]. Chitosan, because of its good biocompatibility and physicochemical properties has been proposed as a biomaterial for tackling peripheral nerve injuries. The Degree of Acetylation (DA) is a key parameter that can be controlled and has a major impact on material properties. According to the literature, decreasing DA leads to greater Schwann cell adhesion [4].

Conference NameTermStem
Date Published2016-01-22
Keywordscell adhesion, Chitosan, nerve repair, Schwann cells
RightsopenAccess
Peer reviewedno
Statuspublished

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