Cancer cell tracking using dendrimer nanoparticles uptake in a microfluidic platform

last updated: 2018-02-22
ProjectNanoTech4ALS :: publications list
TitleCancer cell tracking using dendrimer nanoparticles uptake in a microfluidic platform
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2018
AuthorsCarvalho M. R., Maia F. R., Silva-Correia J., Costa B. M., Reis R. L., and Dr. Oliveira J. M.
Abstract

Statement of Purpose: Circulating tumor cells (CTCs) have been highly studied due to its implication in cancer dissemination and metastases. Thus, an approach capable of hindering their dissemination could help prevent 90% of cancer deaths (1). Labeled nanoparticles (NPs) have been proposed to track cells and monitor the efficiency of any new cancer therapy in real time. The association of NPs to a microfluidic device, such as Vena8 biochips (Figure 2), allows the accomplishment of functions in vitro that are not easily imaginable in conventional biological analysis (e.g., simulation of physiological flow and shear stress). This novel approach may expedite therapies’ validation and its successful translation into clinics. In this study, we aim to develop an improved platform composed of labeled dendrimer nanoparticles and a microfluidic device for real-time monitoring of cancer cells fate.

JournalEuropean Cells and Materials
Conference NameSFB
Volume33(Suppl. 2
PaginationP362
Date Published2018-09-21
ISSN1473-2262
KeywordsCancer, Microfluidics, Nanoparticles
RightsopenAccess
Peer reviewedno
Statuspublished

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