Biomaterials, Biodegradables and Biomimetics Research Group

Review Paper

Biopolymers and Polymers in the Search of Alternative Treatments for Meniscal Regeneration: State of the Art and Future Trends

Abstract

This review focuses on the meniscus and the biomaterials involved in meniscal repair and regeneration. Clinical issues associated with the meniscus are introduced and treatment strategies are discussed in terms of biomaterial choice: extracellular matrix materials (ECM), natural materials (ECM-like), synthetic or hybrids of these. These material choices lead to a myriad of options ranging from permanent implants to biodegradable scaffolds (with and without cells, binding ligands and growth factors). The latest chemistries behind emerging candidate materials are discussed in terms of functional modifications, crosslinking agents and techniques. Finally, we review the latest and promising advances associated with bioprinted meniscal implants and the drive towards more functional bioinks with the overall goal of achieving a patient-specific meniscal implant.

Journal
Applied Materials Today
Volume
12
Issue
2018
Pagination
51-71
Publisher
Elsevier
ISSN
2352-9407
URL
https://www.sciencedirect.com/science/article/pii/S2352940718301410
Keywords
Bioprinting, meniscus, regenerative medicine, Tissue engineering
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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