Biomaterials, Biodegradables and Biomimetics Research Group

Invited Review Paper

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

Abstract

Abstract Drug toxicity frequently goes concealed until clinical trials stage, which is the most challenging, dangerous and expensive stage of drug development. Both the cultures of cancer cells in traditional 2D assays and animal studies have limitations that cannot ever be unraveled by improvements in drug-testing protocols. A new generation of bioengineered tumors is now emerging in response to these limitations, with potential to transform drug screening by providing predictive models of tumors within their tissue context, for studies of drug safety and efficacy. Considering the NCI60, a panel of 60 cancer cell lines representative of 9 different cancer types: leukemia, lung, colorectal, central nervous system (CNS), melanoma, ovarian, renal, prostate and breast, we propose to review current Bstate of art^ on the 9 cancer types specifically addressing the 3D tissue models that have been developed and used in drug discovery processes as an alternative to complement their study

Journal
Stem Cell Rev and Rep
Pagination
1-17
Publisher
Springer
ISSN
1550-8943
URL
https://link.springer.com/article/10.1007/s12015-017-9720-x
Keywords
3D, Biomaterials, Cancer, drug discovery, Tissue engineering
Rights
Open Access
Peer Reviewed
Yes
Status
published
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