Biomaterials, Biodegradables and Biomimetics Research Group

Conference Paper -ISI Web of Science Indexed

In vivo Behaviour of BonelikeÒ/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation

Abstract

The present work consisted in assessing the in vivo biological behaviour of novel Bonelike/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike. This result is strongly encouraging since Bonelike/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules.

Journal
Key Engineering Materials Vols. 254-256
Pagination
565-568
Publisher
Trans Tech Publications Ltd.
Keywords
Bonelike, PQCT
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2007
Date Published
2007-03-16
Search Google ScholarGenerate BibTexDownload RTF
This website uses cookies. By using this website you consent to our use of these cookies. For more information visit our Policy Page.