The repair and regeneration of osteochondral (OC) defects has been increasing owing the high number of trauma related injuries or osteoarthritis. Although current clinical options are effective for the treatment of the OC defects, new therapeutic options are necessary for the complete regeneration of the damaged articular cartilage which has a limited healing capacity. The main purpose for OC tissue engineering is to recreate a biomimetic scaffold consisting of a cartilaginous layer and an underlying osseous layer, for regeneration of cartilage and bone, respectively, involving different combinations of materials, morphologies and properties in both parts of the scaffolds¹. Composite scaffolds composed of biopolymers (silk fibroin) and calcium phosphates incorporating different ions (Sr, Zn), for the simultaneous repair/ regeneration of cartilage and bone are herein developed. These scaffolds present great bioresorbability and osteointegration, and high mechanical strength². In particular, Sr and Zn plays vital roles in the formation, growth, and repair of bone, thus it can promote osteogenesis and angiogenesis³. Besides, these elements can lend controlled degradation and increase the mechanical strength of the biomimetic materials.