Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Photocrosslinked Laminarin based hydrogels for biomedical applications

Abstract

Laminarin is a low-molecular-weight (<10 kDa) glucan found in brown algae made up of β(1→3)-glucan with β(1→6)-branches. This is one of the most abundant carbon sources in the marine ecosystem. Laminarin has been found to possess various biological interesting properties, such as antioxidant and antimicrobial activities. An attractive feature of laminarin is its inherently low viscosity and high solubility in organic and aqueous solvents that facilitate processing. This makes laminarin an appealing material for the development of new hydrogels that can be easily injected through minimally invasive procedures or used for microfabrication of hydrogels. An approach for synthesizing photo-crosslinkable laminarin hydrogels is presented in this work for the first time. Photo-cross-linkable laminarin was prepared by chemical modification with acrylate groups. The synthesized photo-cross-linkable laminarin material provides the basis for the development of a new injectable system for biomedical purposes that could be used alone or with encapsulated cells or biological molecules. The cross-linking of the methacrylated laminarin is straightforward via photoinitiated polymerization. The possibility to control the methacrylation degree of laminarin and to prepare solutions up to at least 15% w/v permits us to obtain hydrogels with tuned and wide range of stiffness and swelling. Furthermore, the encapsulation of human-adipose-derived stem cells encapsulated in the photo-cross-linked hydrogels demonstrated in vitro biocompatibility.

Journal
Biomacromolecules
Volume
17
Pagination
1602-1609
Publisher
ACS
ISSN
1525-7797
URL
http://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b01736
Keywords
Biomaterials, hydrogel, Laminarin
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
ComplexiTE
Year of Publication
2016
DOI
10.1021/acs.biomac.5b01736
Date Published
2016-03-28
Search Google ScholarGenerate BibTexDownload RTF
This website uses cookies. By using this website you consent to our use of these cookies. For more information visit our Policy Page.