Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation

last updated: 2013-07-29
TitlePectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation
Publication TypePapers in Scientific Journals
Year of Publication2013
AuthorsPuga A. M., Lima A. C., Mano J. F., Concheiro A., and Alvarez-Lorenzo C.

5-Fluorouracil(5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly
efficient and environment-friendly way. The size of the microgels (with diameters of ca.280 and 557um for the chitosan seeds and pectin-coated microgels respectively) was the lowest obtained until now using similar biomimetic methodologies. The microgels were characterized regarding 5-FU release pro-files in vitro in aqueous media covering the pH range of the gastrointestinal tract, and cytotoxicity against two cancer cell lines sensitive to 5-FU. Owing to their control of 5-FU release in acidic medium, calcium pectinate-coated microgels can be considered as suitable for oral administration. Growth inhibition of cancer cells by 5-FU was greater when incorporated to chitosan microgels; these being potentially useful for treatment of skin and colorectal tumors.

JournalCarbohydrate Polymers
Date Published2013-05-31
Publisher Elsevier B.V.
KeywordsChitosan, Colorectal cancer, Pectin, pH-responsive release, Skin cancer, superhydrophobic surfaces
Peer reviewedyes

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