Biomaterials, Biodegradables and Biomimetics Research Group

Comunications - Poster

Liquified Capsules Encapsulating Microparticles to Provide Cell Adhesion Sites Enhance Cellular Functions

Abstract

In bioencapsulation, the dense network of hydrogels compared to the liquified environment of capsules jeopardizes the diffusion of essential molecules for cell survival.However, most cells cannot grow in suspension and need to adhere to a solid structure. Encapsulated in the liquified environment of capsules and deprived of a physical support, anchorage-dependent cells are not able to adhere and proliferate. To address this dichotomy we propose the development of a completely new concept of liquified capsules featuring (i) an external shell by layer-by-layer assembly of poly(L-lysine) (PLL), alginate (ALG) and chitosan (CHT), and encapsulating (ii) poly(L-lactic acid) (PLLA) microparticles. We hypothesize that, while the liquified environment enhances the exchange of nutrients, oxygen, metabolites and waste products, microparticles dispersed in the liquified core of capsules provide the physical support required for cellular functions.

Journal
Society for Biomaterials Annual Meeting and Exposition 2013: Biomaterials Revolution
ISSN
1526-7547
ISBN
978-1-62748-128-1
URL
http://toc.proceedings.com/17783webtoc.pdf
Keywords
layer-by-layer, microparticles
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2013
Date Published
2013-04-10
Search Google ScholarGenerate BibTexDownload RTF
This website uses cookies. By using this website you consent to our use of these cookies. For more information visit our Policy Page.