Biomaterials, Biodegradables and Biomimetics Research Group

Review Paper

High-throughput screening for integrative biomaterials design: exploring advances and new trends

Abstract

With the increasing need for biomaterials and tissue engineering alternatives, more accurate, rapid, and cost-saving methods and models to study biomaterial-cell interactions must be developed. We review the evolution of microarray platforms used for such studies in order to meet the criteria of complex tissue engineering biological environments. Particular aspects regarding biomaterials processing, data acquisition, and treatment are addressed. Apart from in vitroarray-based strategies, we also address emerging in vivo high-throughput approaches and their associated trends, such as the role of inflammation in regeneration. The up-scaling of high-throughput methods using single cell encapsulation systems is also explored. Possible limitations related to the use of such methods, such as spot-to-spot crosstalk, are also discussed.
Journal
Trends in Biotechnology
Volume
32
Issue
12
Pagination
627-636
URL
http://www.cell.com/trends/biotechnology/abstract/S0167-7799(14)00191-7
Keywords
Biomaterials, High-throughput screening
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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