Biomaterials, Biodegradables and Biomimetics Research Group

Review Paper

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Abstract

Mechanical stimulus is of upmost importance in tissues developmental and regeneration processes as well as in maintaining body homeostasis. Classical physiological reactions encompass an increase of blood vessel diameter upon exposure to high blood pressure, or the expansion of cortical bone after continuous high-impact exercise. At a cellular level, it is well established that extracellular stiffness, topography, and remote magnetic actuation are instructive mechanical signals for stem cell differentiation. Based on this, biomaterials and their properties can be designed to act as true stem cell regulators, eventually leading to important advances in conventional tissue engineering techniques. This review identifies the latest advances and tremendous potential of magnetic actuation within the scope of regenerative medicine and tissue engineering. 

Journal
Trends in Biotechnology
Volume
33
Issue
8
Pagination
471-479
Publisher
Cell
URL
http://www.sciencedirect.com/science/article/pii/S0167779915001286
Keywords
magnetic actuation, regenerative medicine, Stem cells
Rights
Open Access
Peer Reviewed
Yes
Status
published
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