Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Functionalised collagen-MnO2 fibres inhibit oxidative-induced apoptosis in degenerated IVD

Abstract

Intervertebral disc cell apoptosis has been reported as the major factor responsible in promoting disc degeneration. In this study we hypothesize that collagen fibres with manganese dioxide (MnO2) nanoparticles (NPs) can increase oxygen levels by scavenging ROS species and converting it into byproducts. The specific objective of this study is to fabricate collagen fibres incorporating NPs (Fig. 1), with controlled degradability that are able to scavenge ROS species and generate O2 while inhibiting annulus fibrosus (AF) cell apoptosis under inflamed conditions.

Journal
European Cells & Materials
Volume
31
Edition
1
Issue
1
Pagination
P50
ISSN
14732262
URL
http://www.ecmjournal.org/journal/supplements/vol031supp01/vol031supp01_P.htm
Keywords
Collagen, IL1b, IVD, Manganese dioxide, Nanoparticles, ROS, Scavenging effect
Rights
Open Access
Peer Reviewed
Yes
Status
published
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