Biomaterials, Biodegradables and Biomimetics Research Group

Review Paper

Current Concepts: Tissue Engineering and Regenerative Medicine Applications in the Ankle Joint

Abstract

Tissue engineering and regenerative medicine (TERM) has caused a revolution in present and future trends of medicine and surgery. In different tissues, advanced TERM approaches bring new therapeutic possibilities in either general population as in young patients and high-level athletes, improving restoration of biological functions and rehabilitation. The mainstream components required to obtain a functional regeneration of tissues may include biodegradable scaffolds, drugs or growth factors and different cell types (either autologous or heterologous) that can be cultured in bioreactor systems (in vitro) prior implantation into the patient. Particularly in the ankle, that is subject of many different injuries (e.g. acute, chronic, traumatic, degenerative), there is still no definitive and feasible answer to “conventional” methods. This review aims to provide current concepts of TERM applications to ankle injuries under pre-clinical and/or clinical research applied to skin, tendon, bone and cartilage problems. A particular attention has been given to biomaterials design and scaffolds processing with potential use in osteochondral ankle lesions.

Journal
Journal of the Royal Society Interface
Volume
11
Issue
92
Pagination
20130784
Publisher
Royal Society Publishing
URL
http://rsif.royalsocietypublishing.org/content/11/92/20130784.full
Keywords
Ankle, Biomaterials, Osteochondral lesions, regenerative medicine, Scaffold, Tissue engineering
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2013
DOI
10.1098/​rsif.2013.0784
Date Published
2013-12-18
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