Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

Abstract

 The development of controlled release systems for the regeneration of bone, cartilage, and osteochondral interface is one of the hot topics in the field of tissue engineering and regenerative medicine. However, the majority of the developed systems consider only the release of a single growth factor, which is a limiting step for the success of the therapy. More recent studies have been focused on the design and tailoring of appropriate combinations of bioactive factors to match the desired goals regarding tissue regeneration. In fact, considering the complexity of extracellular matrix and the diversity of growth factors and cytokines involved in each biological response, it is expected that an appropriate combination of bioactive factors could lead to more successful outcomes in tissue regeneration. In this review, the evolution on the development of dual and multiple bioactive factor release systems for bone, cartilage, and osteochondral interface is overviewed, specifically the relevance of parameters such as dosage and spatiotemporal distribution of bioactive factors. A comprehensive collection of studies focused on the delivery of bioactive factors is also presented while highlighting the increasing impact of platelet-rich plasma as an autologous source of multiple growth factors.

Journal
Tissue Engineering: Part B
Volume
19
Issue
4
Pagination
327-352
Publisher
Mary Ann Liebert, Inc.
URL
http://online.liebertpub.com/doi/abs/10.1089/ten.TEB.2012.0727?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Keywords
controlled release, tisssue engineering
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2013
DOI
10.1089/ten.TEB.2012.0727
Date Published
2013-06-20
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